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Maxim Raginsky's avatar

You'll enjoy this pithy little chestnut from Charles Geyer:

"The story about n going to infinity is even less plausible in spatial statistics and statistical genetics where every component of the data may be correlated with every other component. Suppose we have data on school districts of Minnesota. How does Minnesota go to infinity? By invasion of surrounding states and provinces of Canada, not to mention Lake Superior, and eventually by rocket ships to outer space? How silly does the n goes to infinity story have to be before it provokes laughter instead of reverence?"

Read the whole thing, it's worth it: https://www.stat.umn.edu/geyer/lecam/simple.pdf

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Robin ince's avatar

One idea for “what else can we do?” is here: https://doi.org/10.1016/j.tics.2022.05.008 In cognitive science we can treat each participant as a replication of an N=1 study, then formally quantify how this generalises to the population by estimating the population-level experimental replication probability (the prevalence): https://elifesciences.org/articles/62461 I think this approach could also be useful in other areas.

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